2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NEDD8-activating Enzyme
  5. NEDD8-activating Enzyme Inhibitor

NEDD8-activating Enzyme Inhibitor

NEDD8-activating Enzyme Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-70062
    Pevonedistat
    		Inhibitor 99.98%
    Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM.
  • HY-10484
    Pevonedistat hydrochloride
    		Inhibitor 99.19%
    Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM.
  • HY-128586
    TAS4464
    		Inhibitor 99.52%
    TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
  • HY-128586A
    TAS4464 hydrochloride
    		Inhibitor 98.12%
    TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM. TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-111505
    NAcM-OPT
    		Inhibitor 99.65%
    NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.
  • HY-101790A
    ZM223 hydrochloride
    		Inhibitor 99.21%
    ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.
  • HY-101790
    ZM223
    		Inhibitor
    ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
  • HY-161268
    NAE-IN-1
    		Inhibitor
    NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity.